• ACE-031 recombinant fusion protein lyophilised powder for TGF-β signaling research
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CoreX Peptides

ACE-031

ACE-031

£44.99 GBP
£44.99 GBP
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ACE-031 is a recombinant fusion protein that combines the extracellular ligand-binding domain of activin receptor type IIB (ActRIIB) with the Fc portion of human IgG1. This structurally defined soluble receptor construct is designed for experimental investigation of ligand-receptor interactions within the transforming growth factor-beta (TGF-β) superfamily. In biochemical and cellular research systems,

ACE-031 functions as a decoy receptor capable of binding select TGF-β family ligands, including myostatin (GDF-8) and activins. By binding these ligands, ACE-031 prevents their interaction with endogenous cell-surface receptors, facilitating studies of ligand binding affinity, downstream signaling modulation, and pathway inhibition under controlled conditions. The observed molecular responses depend on experimental design, ligand availability, and model system, and are used primarily to explore mechanisms of TGF-β signaling rather than to produce biological or physiological outcomes.

Applications in Research

  • As a molecular tool for studying myostatin and activin ligand binding
  • Investigation of TGF-β superfamily signaling regulation
  • In vitro studies examining receptor-ligand sequestration mechanisms
  • Use as a reference construct in fusion protein and decoy receptor research

Product Specifications:

  • Form: Lyophilised powder
  • Purity: ≥99% verified by HPLC
  • Storage: −20°C, protected from light and moisture
  • Available size: 10mg

⚠ For research purposes only. This product is not intended for human or veterinary use, consumption, or self-administration. Must be handled by qualified professionals in a suitable laboratory environment. Not evaluated by the MHRA or any regulatory authority for therapeutic use.

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Frequently Asked Questions

What is ACE-031 and how is it used in research?
ACE-031 is a recombinant fusion protein designed for experimental investigation of ligand-receptor interactions within the TGF-β superfamily, primarily used to study signaling mechanisms involving myostatin and activins. It functions as a soluble receptor, allowing researchers to examine ligand binding affinity and pathway modulation in biochemical and cellular research systems.
How does ACE-031 function as a decoy receptor in ligand binding studies?
As a decoy receptor, ACE-031 binds to select TGF-β family ligands such as myostatin and activins, preventing their interaction with native cell-surface receptors. This ligand sequestration capability is useful for studying receptor–ligand mechanisms and signaling regulation in vitro.
What are the storage and handling requirements for ACE-031?
ACE-031 should be stored as a lyophilised powder at −20°C, protected from light and moisture. It must be handled by qualified professionals in a controlled laboratory environment, as it is intended solely for research purposes.